Quantitative Biology > Tissues and Organs
[Submitted on 9 Mar 2024
]
Title: An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis
Title: 一种基于计算机的半月板组织再生方法：建模、数值模拟和实验分析
Abstract: We develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics.
Submission history
From: Christina Surulescu [view email][v1] Sat, 9 Mar 2024 13:24:55 UTC (10,157 KB)
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