Title: Lagrangian analysis of turbulent blood flow in the human left heart Show Chinese title

Title: 左心湍流血流的拉格朗日分析

Abstract: We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI) framework, we track the motion of Lagrangian (passive) tracers to investigate the multiscale statistical properties of velocity fluctuations over more than four decades. Our analysis reveals strong Lagrangian intermittency throughout the left heart, reflecting the complex and unsteady nature of cardiovascular flow. The present work underscores the sensitivity of Lagrangian statistics to physiological parameters and highlights their potential for improving the understanding of pathological flow conditions in cardiovascular systems. Such Lagrangian tool provides a statistical foundation for modeling shear-induced damage in red blood cells (hemolysis), with implications for the evaluation of prosthetic valves and blood-contacting medical devices. Show Chinese abstract

Abstract: 我们使用基于患者特异性解剖模型的高保真模拟，对人类左心的湍流血液流动进行了拉格朗日分析。 利用完全耦合的流体-结构-电生理相互作用（FSEI）框架，我们追踪拉格朗日（被动）示踪粒子的运动，以研究超过四个数量级的速度波动的多尺度统计特性。 我们的分析揭示了左心室中存在强烈的拉格朗日间歇性，反映了心血管流动的复杂和不稳定性质。 本研究强调了拉格朗日统计对生理参数的敏感性，并突显了它们在改善对心血管系统病理流动条件理解方面的潜力。 这种拉格朗日工具为建模红细胞（溶血）引起的剪切损伤提供了统计基础，对评估人工瓣膜和血液接触类医疗设备具有重要意义。