标题： 人工增强刚性的红细胞的迁移 显示英文标题

标题： Margination of artificially stiffened red blood cells

摘要： 白细胞从流动的血液迁移到血管壁的基本过程称为边缘化，在生理学中已有充分记载。然而，白细胞和红细胞在细胞大小和刚性方面的差异如何影响这一现象，仍然是一个开放性问题。为了研究细胞刚性对这一现象的具体影响，我们对人工增硬的红细胞在健康细胞悬浮液中的分离进行了实验和数值研究。结果发现，增硬细胞在通道中的分布取决于通道几何形状，如狭缝、矩形和圆柱形截面。值得注意的是，在模拟结果一致的情况下，增硬红细胞的分布出现了一个意外的中心峰值，以及四个角落处的四重峰值。我们的结果揭示了血细胞比容和流速与分离/边缘化之间的非单调变化，这挑战了当前认为较高流速会增强边缘化的观点。 显示英文摘要

摘要： Margination, a fundamental process in which leukocytes migrate from the flowing blood to the vessel wall, is well-documented in physiology. However, it is still an open question on how the differences in cell size and stiffness of white and red cells contribute to this phenomenon. To investigate the specific influence of cell stiffness, we conduct experimental and numerical studies on the segregation of a binary mixture of artificially stiffened red blood cells within a suspension of healthy cells. The resulting distribution of stiffened cells within the channel is found to depend on the channel geometry, as demonstrated with slit, rectangular, and cylindrical cross-sections. Notably, an unexpected central peak in the distribution of stiffened RBCs, accompanied by fourfold peaks at the corners, emerges in agreement with simulations. Our results unveil a non-monotonic variation in segregation/margination concerning hematocrit and flow rate, challenging the prevailing belief that higher flow rates lead to enhanced margination.