标题： 中子相对效能因子在硼中子俘获治疗中的应用：从次级带电粒子估算其数值并评估标准组织的加权吸收剂量因子 显示英文标题

标题： Neutron relative effectiveness factors in Boron Neutron Capture Therapy: estimation of their values from the secondary charged particles and evaluation of weighted kerma factors for a standard tissue

摘要： 中子照射在BNCT治疗背景下的平均相对生物学效应（RBE）因子被研究。 这项研究考虑了每个过程的各种相互作用和次级粒子，并根据这些粒子在组织中引起的损伤来估算RBE。 引入了一种通过加权kerma因子估算生物剂量的新概念。 这些加权kerma因子包括基于次级带电粒子的RBE-LET关系的每个能量沉积的RBE，并可以直接用于蒙特卡罗模拟的加权剂量计算中。 此外，讨论了标准软组织中中子加权因子与中子能量的依赖关系。 显示英文摘要

摘要： The average Relative Biological effectiveness (RBE) factors for neutron irradiation in the context of a BNCT treatment are studied. This research considers the various interactions and secondary particles of each process and estimates the RBE based on the damage induced in tissues by all of these particles. A novel concept of estimating the biological dose by means of weighted kerma factors is introduced. These weighted kerma factors include the RBE of each energy deposition based on an RBE-LET relationship for secondary charged particles and can be directly incorporated in weighted dose calculations from Monte Carlo simulations. Furthermore, the dependence of the neutron weighting factor on neutron energy for standard soft tissue is discussed.