标题： 4D打印辅助支架形成心脏砖块 显示英文标题

标题： 4D-Printing Assisted Scaffolds to Form Cardiac Bricks

摘要： 心肌梗死导致心肌变薄、纤维化和进行性心力衰竭。 工程化人类心肌（EHM）作为首个同类产品在临床上进行测试，用于晚期心力衰竭患者的可持续再肌肉化。 目前从iPSC衍生的心肌细胞和基质细胞生产的EHM工艺耗时且涉及较薄的结构。 在这里，我介绍一种4D-DLP打印的可折叠支架，有望创建模块化的圆柱形心脏砖块。 这使得自组装形成更厚且对齐的肌节，具有同步收缩能力，模仿天然心肌。 当优化并与冷冻保存协议整合时，这些细胞建筑模块的生物制造和生物银行可能克服当前EHM的局限性，并推进心肌梗死的转化再生疗法。 对这些新型生命建筑模块的结构-材料特性研究为未来的医学突破铺平了道路。 显示英文摘要

摘要： Myocardial infarction causes myocardium thinning, fibrosis, and progressive heart failure. Engineered human myocardium (EHM) is tested clinically as a first-in-class product for sustainable remuscularization in patients with advanced heart failure. Current EHM production procedure from iPSC-derived cardiomyocytes and stromal cells, is time consuming and involves thin constructs. Here, I introduce 4D-DLP-printed foldable scaffolds with potential to create modular cylindrical cardiac bricks. This enables self-assembly into thicker and aligned sarcomeres with synchronous contractility mimicking a native myocardium. When optimized and integrated with cryopreservation protocols, the biomanufacturing and biobanking of these cellular building blocks may overcome current EHM limitations and advance translational regenerative therapies for myocardial infarction. The structure-material properties investigations into these new class of life building blocks paves the way for future medical breakthroughs.