标题： 体内研究增材制造植入物周围骨生长的钛-6铝-4钒与生物活性玻璃粉复合材料 显示英文标题

标题： In Vivo Study of Bone Growth Around Additively Manufactured Implants with Ti-6Al-4V and Bioactive Glass Powder Composites

摘要： 骨整合对于生物医学植入物的成功至关重要。 增材制造植入物提供了高度的设计自由度，能够精确控制植入物的几何形状和材料组成。 生物活性玻璃（BG）可以显著增强骨结合和生物活性；然而，关于其在增材制造植入物中的应用研究有限。 BG的性能取决于其掺入方法，其整合的空间和时间演变仍不明确。 在本研究中，我们采用选择性激光熔化方法合成了Ti-6Al-4V/58S BG复合材料，并系统比较了增材制造植入物中BG涂层和掺杂的效果。 对动物试验的体内组织学结果进行了统计分析，并讨论了在4周和12周时间段内的骨整合情况。 骨与植入物接触（BIC）和骨密度（BD）被用作定量指标，以评估植入物与周围骨组织之间的相互作用。 我们的研究结果表明，BG掺杂和BG涂层的植入物在愈合早期阶段都加速了骨长入。 BG涂层的植入物表现出比纯3D打印的Ti-6Al-4V植入物更大的改善。 然而，在愈合后期阶段（12周），BG的影响变得不显著。 本研究为系统研究BG在3D打印生物医学植入物中的掺入方法及其对骨整合的影响提供了基础。 显示英文摘要

摘要： Osseointegration is crucial to the success of biomedical implants. Additive manufacturing of implants offers a high degree of design freedom, enabling precise control over implant geometry and material composition. Bioactive glass (BG) can substantially enhance bone binding and bioactivity; however, limited research has been conducted on its incorporation into additively manufactured implants. The performance of BG varies depending on the incorporation method, and the spatial and temporal evolution of its integration remains unclear. In this study, we synthesized Ti-6Al-4V/58S BG composites by using the selective laser melting method and systematically compared the effects of BG coating and doping in additively manufactured implants. In vivo histological results from animal tests were statistically analyzed and discussed in terms of osseointegration over 4- and 12-week periods. Bone-to-implant contact (BIC) and bone density (BD) were used as quantitative metrics to evaluate interactions between the implants and surrounding bone. Our findings indicate that both BG-doped and BG-coated implants accelerated bone ingrowth during the early stages of healing. BG-coated implants demonstrated a greater improvement than did pure 3D-printed Ti-6Al-4V implants. However, the effects of BG became nonsignificant during the later healing stage (12 weeks). This study provides a foundation for systematically investigating BG incorporation methods in 3D-printed biomedical implants and their effect on osseointegration.