标题： LAGE：一个用于从大规模连续表达数据重建基因调控网络的 Java 框架 显示英文标题

标题： LAGE: A Java Framework to reconstruct Gene Regulatory Networks from Large-Scale Continues Expression Data

摘要： LAGE 是用 Java 开发的一个系统框架。 LAGE 的动机是提供一种可扩展且并行的解决方案，从连续的基因表达数据中重建基因调控网络（GRNs），适用于大量基因的情况。 我们框架的基本思想受到分而治之哲学的启发。 具体来说，LAGE 递归地将基因划分为多个较小规模的重叠社区，分别学习每个社区内的 GRNs，然后将它们合并在一起。 此外，重叠社区的完整信息作为副产品，可用于挖掘生物网络中有意义的功能模块。 显示英文摘要

摘要： LAGE is a systematic framework developed in Java. The motivation of LAGE is to provide a scalable and parallel solution to reconstruct Gene Regulatory Networks (GRNs) from continuous gene expression data for very large amount of genes. The basic idea of our framework is motivated by the philosophy of divideand-conquer. Specifically, LAGE recursively partitions genes into multiple overlapping communities with much smaller sizes, learns intra-community GRNs respectively before merge them altogether. Besides, the complete information of overlapping communities serves as the byproduct, which could be used to mine meaningful functional modules in biological networks.