标题： 细胞局部粘弹性的旋转磁谱测量 显示英文标题

标题： Local viscoelasticity of living cells measured by rotational magnetic spectroscopy

摘要： 当置于磁场中时，具有超顺磁特性的微米尺寸的导线表现为嵌入式流变仪，并作为微流变学的有趣传感器。 在这里，我们使用旋转磁谱学来测量活细胞胞质的剪切粘度。 我们探讨了胞质是粘弹性液体还是凝胶的问题。 研究的主要结果是观察到同步和异步旋转模式之间的旋转不稳定性，这在小鼠成纤维细胞和人癌细胞中发现。 对于磁化率3.6的导线，转变发生在0.01...1 rad s-1范围内。 剪切粘度（10...100 Pa s）和弹性模量（5...20 Pa）的确定证实了胞质的粘弹性特性。 与早期研究不同，得出的结论是，活细胞的内部可以描述为粘弹性液体，而不是弹性凝胶。 显示英文摘要

摘要： When submitted to a magnetic field, micron size wires with superparamagnetic properties behave as embedded rheometers and represent interesting sensors for micro-rheology. Here we use rotational magnetic spectroscopy to measure the shear viscosity of the cytoplasm of living cells. We address the question of whether the cytoplasm is a viscoelastic liquid or a gel. The main result of the study is the observation of a rotational instability between a synchronous and an asynchronous regime of rotation, found for murine fibroblasts and human cancer cells. For wires of susceptibility 3.6, the transition occurs in the range 0.01...1 rad s-1. The determination of the shear viscosity (10...100 Pa s) and elastic modulus (5...20 Pa) confirms the viscoelastic character of the cytoplasm. In contrast to earlier studies, it is concluded that the interior of living cells can be described as a viscoelastic liquid, and not as an elastic gel.