标题： 固定条件下的高产可寻址复杂性的分层自组装 显示英文标题

标题： Hierarchical self-assembly for high-yield addressable complexity at fixed conditions

摘要： 有证据表明，复杂分子系统的自组装通常按层次进行，首先构建亚基，然后这些亚基组装成更大的实体，这一过程可以重复多次。 然而，我们对这一现象及其性能的理解是有限的。 在这里，我们引入了一个简单的分层可寻址自组装模型，其中粒子之间的相互作用可以被优化，以最大化良好形成的靶结构或产物的比例。 我们发现，分层策略可以导致令人印象深刻的产品产量，至少可以达到五代层次，并且不需要像以前方法中使用的温度循环。 当微观相互作用随着所考虑单元的规模而减小时，可以获得高产量，这样中间结构之间的总相互作用在所有尺度上保持相同。 我们提供了热力学和动力学论据，限制了该策略有效的相互作用强度。 总体而言，我们的工作描述了一种在固定温度下可寻址自组装的替代策略，并为生物中维持分层组装的机制提供了见解。 显示英文摘要

摘要： There is evidence that the self-assembly of complex molecular systems often proceeds hierarchically, by first building subunits that later assemble in larger entities, in a process that can repeat multiple times. Yet, our understanding of this phenomenon and its performance is limited. Here we introduce a simple model for hierarchical addressable self-assembly, where interactions between particles can be optimised to maximise the fraction of a well-formed target structure, or yield. We find that a hierarchical strategy leads to an impressive yield up to at least five generations of the hierarchy, and does not require a cycle of temperatures as used in previous methods. High yield is obtained when the microscopic interaction decreases with the scale of units considered, such that the total interaction between intermediate structures remains identical at all scales. We provide thermodynamic and dynamical arguments constraining the interaction strengths where this strategy is effective. Overall, our work characterizes an alternative strategy for addressable self-assembly at a fixed temperature, and provides insight into the mechanisms sustaining hierarchical assembly in biology.