标题： 患者激活和硼中子俘获治疗后的剂量测定评估 显示英文标题

标题： Evaluation of patient activation and dosimetry after Boron Neutron Capture Therapy

摘要： 硼中子俘获治疗（BNCT）是一种基于在给予富含硼-10的选择性药物后，用低能中子束照射肿瘤的放射治疗方法。 该治疗利用了热中子在硼中的高截面，产生两种低射程的带电粒子。 能够通过质子核反应生成高强度中子束的加速器的出现正在推动新临床中心的建设。 其中一个是正在意大利开发的，使用一个5 MeV、30 mA的质子射频加速器耦合到铍靶，由补充计划资助，该计划是恢复和韧性国家计划的一部分，项目名为ANTHEM。 本研究关注接受BNCT治疗的患者的辐射防护方面，特别是其器官和组织的活化。 已经提出了一种确定BNCT后这种活化相关性的标准。 根据当前的意大利法规框架，BNCT治疗后患者的活化水平在照射后不久并不会造成显著的放射学问题。 另一个方面是患者排泄物的活化，这可能会影响建筑的设计，并需要一个排放过程。 所述研究为意大利ANTHEM BNCT中心的辐射防护研究做出了贡献。 显示英文摘要

摘要： Boron Neutron Capture Therapy (BNCT) is a form of radiotherapy based on the irradiation of the tumour with a low energy neutron beam, after the administration of a selective drug enriched in boron-10. The therapy exploits the high cross section of thermal neutron capture in boron, generating two low-range charged particles. The availability of accelerators able to generate high-intensity neutron beams via proton nuclear interaction is boosting the construction of new clinical centres. One of these is under development in Italy, using a 5 MeV, 30 mA proton radiofrequency accelerator coupled to a beryllium target, funded by the Complementary Plan to the Recovery and Resilience National Plan, under the project ANTHEM. The present study focuses on radiation protection aspects of patients undergoing BNCT, specifically on the activation of their organs and tissues. A criterion to establish the relevance of such activation after BNCT has been proposed. Based on the current Italian regulatory framework, the level of patient activation following BNCT treatment does not pose a significant radiological concern, even shortly after irradiation. Another aspect is the activation of patient's excretions, which can impact on the design of the building and requires a process for the discharge. The described study contributes to the radiation protection study for the ANTHEM BNCT centre in Italy.