标题： 医学物理数据集文章：FLASH小鼠在体研究数据库 显示英文标题

标题： Medical Physics Dataset Article: a database of FLASH Murine In-Vivo Studies

摘要： FLASH效应指的是在等效肿瘤反应下，正常组织损伤较低，这可能扩大放射治疗的治疗窗口。 尽管在使用不同类型的粒子和照射参数的各种实验中已经证明了这一效应，但其潜在机制尚不明确。 关于所进行的实验、探索的参数空间以及报告结果的变异性存在不确定性。 为了更好地全面了解，我们创建了一个包含体内FLASH实验的数据集。 该数据集记录了所有机器和生物剂量学参数，并且对于确定的终点，还包括了实验结果。 我们的目标是提高对结果及其变异性认识，并为社区提供一个有用的研究和分析工具。 该数据库包含截至2024年3月发表的关于体内FLASH（小鼠）实验的同行评审论文。 从每篇论文中，已手动提取和/或重新计算了先前定义的参数，以确保数据库条目之间的兼容性。 我们提供了两种类型的数据集：一个用户友好的基于网络的Notion数据库和Zenodo存储库上的电子表格。 该数据库包含所有经过审查的论文，其中包含以文本或数值形式提取的信息。 用户可以复制数据库或在线查看、搜索、筛选和重新组织条目。 电子表格包含最常分析的终点数据，允许进行比较分析。 该研究有两个主要应用。 基于网络的数据库将允许用户友好地搜索所有已发表的FLASH小鼠数据的信息和元数据。 这将促进未来的研究努力，以更好地理解FLASH效应。 电子表格是社区进行统计分析并确定与FLASH效应相关的参数的简单而有用的工具。 显示英文摘要

摘要： The FLASH effect refers to a lower normal tissue damage for an equivalent tumour response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types of particles and irradiation parameters, the underlying mechanism is not yet clearly understood. Uncertainties surround the conducted experiments, the explored parameter space, and the variability of reported results. To gain a better overview, we created a dataset that includes in-vivo FLASH experiments. This dataset documents all machine and biological dosimetric parameters, and for determined endpoints, it includes the outcome of the experiment. Our goal is to increase awareness of the results and their variability and provide a useful research and analysis tool for the community. The database contains peer-reviewed papers published until March 2024 on the FLASH in-vivo (murine) experiments. From each paper, previously defined parameters have been manually extracted and/or recalculated to ensure compatibility within the database entries. We provide two types of datasets: a user-friendly web-based Notion database and spreadsheets on a Zenodo repository. The database contains all the reviewed papers with extracted information in text or numeric form. Users can duplicate the database or view, search, filter, and reorganise online entries. The spreadsheets contain the data for the most analysed endpoints, allowing a comparative analysis. The study has two main applications. The web-based database will allow for a user-friendly search of information and meta-data of all published FLASH murine data. This will facilitate future research efforts to better understand the FLASH effect. The spreadsheets are a simple and useful tool for the community to conduct statistical analysis and determine the parameters associated with the FLASH effect.