标题： 壳聚糖与生物基表面活性剂之间的氢键驱动相互作用：体相行为和表面吸附的研究 显示英文标题

标题： Hydrogen bond-driven interactions between chitosan and biobased surfactants: A study of bulk behavior and surface adsorption

摘要： 本研究探讨了壳聚糖（CHI）与烷基葡萄糖苷（APG）在不同离子强度的酸性条件下，通过氢键介导的相互作用。与依赖静电作用的常规聚电解质-表面活性剂相互作用不同，该体系中的相互作用纯粹依赖于非离子相互作用。利用紫外可见光谱、相图和带有耗散监测的石英晶体微天平（QCM-D），研究了CHI-APG混合物在带负电荷表面上的体相行为和吸附特性。结果表明，APG浓度控制相行为，中等水平诱导凝聚物形成，而较高的离子强度通过增强氢键相互作用促进这种凝聚作用。这种转变导致形成相分离形态，在溶液中可观察到微米级的凝聚物液滴。Zeta电位测量表明，这些液滴采用核壳结构，由于表面活性剂的烷基链形成疏水核心，而壳聚糖形成亲水外壳。此外，凝聚过程显著增强了CHI APG复合物在固体基底上的吸附，这一特性在靶向输送和控释系统中具有潜在应用。总体而言，本研究为生物基可持续配方的设计提供了关键见解，并扩展了对氢键驱动的非静电凝聚的理解，这对于化妆品、生物医学涂层和环保材料的应用具有重要意义。 显示英文摘要

摘要： This study explores the hydrogen bond-mediated association between chitosan (CHI) and alkyl polyglucoside (APG), a bio-based surfactant, in acidic conditions with varying ionic strengths. Unlike conventional polyelectrolyte-surfactant interactions that depend on electrostatic forces, the association in this system relies purely on non-ionic interactions. Using UV visible spectroscopy, phase diagrams, and quartz crystal microbalance with dissipation monitoring (QCM-D), the bulk phase behavior and adsorption characteristics of CHI-APG mixtures on negatively charged surfaces was studied. Results demonstrate that APG concentration controls the phase behavior, with moderate levels inducing coacervate formation, while higher ionic strengths promote this coacervation through enhanced hydrogen bonding interactions. This shift leads to the formation of a phase separated morphology, with micronsized coacervate droplets observable in solution. Zeta potential measurements suggest that these droplets adopt a core shell structure, characterized by a hydrophobic core due to the surfactant s alkyl chains and a hydrophilic shell formed by chitosan. Additionally, the coacervation process significantly enhances the adsorption of CHI APG complexes onto solid substrates, a feature with potential applications in targeted delivery and controlled release systems. Overall, this study provides critical insights into the design of bio-based, sustainable formulations and expands the understanding of hydrogen bond-driven, nonelectrostatic coacervation, relevant for applications in cosmetics, biomedical coatings, and environmentally friendly materials.