标题： 利用高光学非线性克服光散射 显示英文标题

标题： Overcoming light scattering with high optical nonlinearity

摘要： 在生物显微镜中，实现在异质和散射介质深处的高分辨率光学成像仍然是一个基本挑战，其中传统技术受到多次光散射和吸收的阻碍。 在这里，我们提出了一种非侵入式成像方法，该方法利用了发光标记的非线性响应，并结合了斑点图案的统计和空间特性——这是随机光干涉的效果。 使用具有强光致发光非线性的雪崩纳米颗粒（ANPs），我们证明了随机斑点照明可以转化为一个局部的、亚衍射的激发光斑。 该光斑可以通过角度记忆效应在样品上扫描，从而实现通过散射层的高分辨率成像。 我们的方法具有普遍性、快速性和成本效益。 它不需要波前整形、不需要反馈，也不需要重建算法，为通过复杂介质进行深层高分辨率成像提供了一条强大的新途径。 显示英文摘要

摘要： Achieving high-resolution optical imaging deep within heterogeneous and scattering media remains a fundamental challenge in biological microscopy, where conventional techniques are hindered by multiple light scattering and absorption. Here, we present a non-invasive imaging approach that harnesses the nonlinear response of luminescent labels in conjunction with the statistical and spatial properties of speckle patterns - an effect of random light interference. Using avalanching nanoparticles (ANPs) with strong photoluminescence nonlinearity, we demonstrate that random speckle illumination can be converted into a single, localized, sub-diffraction excitation spot. This spot can be scanned across the sample using the angular memory effect, enabling high-resolution imaging through a scattering layer. Our method is general, fast, and cost-effective. It requires no wavefront shaping, no feedback, and no reconstruction algorithm, offering a powerful new route to deep, high-resolution imaging through complex media.