标题： 克服高光学非线性下的光散射 显示英文标题

标题： Overcoming light scattering with high optical nonlinearity

摘要： 实现高分辨率光学成像深入异质和散射介质仍然是生物显微镜中的一个基本挑战，传统的技术受到多次光散射和吸收的阻碍。 在这里，我们提出了一种非侵入性成像方法，该方法利用了发光标签的非线性响应以及斑点图案的统计和空间特性——这是随机光干涉的结果。 使用具有强光致发光非线性的雪崩纳米粒子（ANPs），我们证明随机斑点照明可以转换成一个单一的、局部化的、亚衍射激发光斑。 这个光斑可以通过角度记忆效应在整个样本上扫描，从而实现在散射层通过的高分辨率成像。 我们的方法通用、快速且成本低廉。 它不需要波前整形，无需反馈，也无需重建算法，提供了一种强大的新途径，可通过复杂介质实现深层高分辨率成像。 显示英文摘要

摘要： Achieving high-resolution optical imaging deep within heterogeneous and scattering media remains a fundamental challenge in biological microscopy, where conventional techniques are hindered by multiple light scattering and absorption. Here, we present a non-invasive imaging approach that harnesses the nonlinear response of luminescent labels in conjunction with the statistical and spatial properties of speckle patterns - an effect of random light interference. Using avalanching nanoparticles (ANPs) with strong photoluminescence nonlinearity, we demonstrate that random speckle illumination can be converted into a single, localized, sub-diffraction excitation spot. This spot can be scanned across the sample using the angular memory effect, enabling high-resolution imaging through a scattering layer. Our method is general, fast, and cost-effective. It requires no wavefront shaping, no feedback, and no reconstruction algorithm, offering a powerful new route to deep, high-resolution imaging through complex media.