标题： 一种将三维超声整合到经皮肝肿瘤消融中的新框架 显示英文标题

标题： A Novel Framework for Integrating 3D Ultrasound into Percutaneous Liver Tumour Ablation

摘要： 三维超声（US）成像在提高经皮肝肿瘤消融术的疗效方面显示出显著优势。其临床整合对于将三维超声引入治疗领域至关重要。然而，超声图像中肿瘤识别的挑战仍然阻碍了其更广泛的应用。在本研究中，我们提出了一种将三维超声整合到标准消融流程中的新框架。我们提出一个关键组件，一种临床可行的二维超声-CT/MRI配准方法，利用三维超声作为中间媒介以降低配准复杂度。为了促进配准流程的有效验证，我们还提出了一种直观的多模态图像可视化技术。在我们的研究中，二维超声-CT/MRI配准实现了大约2-4毫米的地标距离误差，每对图像的运行时间为0.22秒。此外，非刚性配准相比刚性配准将平均对齐误差减少了约40%。结果表明了所提出的二维超声-CT/MRI配准流程的有效性。我们的集成框架提升了三维超声成像在改善经皮肿瘤消融术中的能力，展示了三维超声在临床干预中扩展治疗作用的潜力。 显示英文摘要

摘要： 3D ultrasound (US) imaging has shown significant benefits in enhancing the outcomes of percutaneous liver tumour ablation. Its clinical integration is crucial for transitioning 3D US into the therapeutic domain. However, challenges of tumour identification in US images continue to hinder its broader adoption. In this work, we propose a novel framework for integrating 3D US into the standard ablation workflow. We present a key component, a clinically viable 2D US-CT/MRI registration approach, leveraging 3D US as an intermediary to reduce registration complexity. To facilitate efficient verification of the registration workflow, we also propose an intuitive multimodal image visualization technique. In our study, 2D US-CT/MRI registration achieved a landmark distance error of approximately 2-4 mm with a runtime of 0.22s per image pair. Additionally, non-rigid registration reduced the mean alignment error by approximately 40% compared to rigid registration. Results demonstrated the efficacy of the proposed 2D US-CT/MRI registration workflow. Our integration framework advanced the capabilities of 3D US imaging in improving percutaneous tumour ablation, demonstrating the potential to expand the therapeutic role of 3D US in clinical interventions.