标题： 一种用于痴呆和心理测验的潜在过程模型 显示英文标题

标题： A Latent Process Model for Dementia and Psychometric Tests

摘要： 我们联合建模了一种心理测量测试的纵向值和痴呆症的诊断。 该模型基于一个连续时间潜在过程来表示认知能力。 潜在过程与观测值之间的联系通过两个阶段进行建模。 中间变量是对潜在过程的噪声观测；心理测量测试的分数和痴呆症的诊断是通过对这些中间变量进行分类得到的。 我们提出了该模型的最大似然推理方法，并提出了执行此任务的算法。 我们使用PAQUID研究五年的随访数据估计了此类模型的参数。 特别是，这项分析得出了关于教育水平对潜在认知能力和迷你精神状态检查特定表现影响的有趣结果。 该模型的预测能力通过基于前五年信息预测PAQUID研究八年随访的痴呆症诊断进行了说明。 显示英文摘要

摘要： We jointly model longitudinal values of a psychometric test and diagnosis of dementia. The model is based on a continuous-time latent process representing cognitive ability. The link between the latent process and the observations is modeled in two phases. Intermediate variables are noisy observations of the latent process; scores of the psychometric test and diagnosis of dementia are obtained by categorizing these intermediate variables. We propose maximum likelihood inference for this model and we propose algorithms for performing this task. We estimated the parameters of such a model using the data of the five-year follow-up of the PAQUID study. In particularThis analysis yielded interesting results about the effect of educational level on both latent cognitive ability and specific performance in the mini mental test examination. The predictive ability of the model is illustrated by predicting diagnosis of dementia at the eight-year follow-up of the PAQUID study bsed on the information of the first five years.