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Quantitative Biology > Neurons and Cognition

arXiv:2106.04651 (q-bio)
[Submitted on 8 Jun 2021 ]

Title: The whole prefrontal cortex is premotor cortex

Title: 整个前额叶皮质都是 premotor 皮质

Authors:Justin M. Fine, Benjamin Y. Hayden
Abstract: We propose that the entirety of the prefrontal cortex can be seen as fundamentally premotor in nature. By this, we mean that the prefrontal cortex consists of an action abstraction hierarchy whose core function is the potentiation and depotentiation of possible action plans at different levels of granularity. We argue that the apex of the hierarchy should revolve around the process of goal selection, which we posit is inherently a form of abstract action optimization. Anatomical and functional evidence supports the idea that this hierarchy originates on the orbital surface of the brain and extends dorsally to motor cortex. Our view, therefore, positions the orbitofrontal cortex as the central site for the optimization of goal selection policies, and suggests that other proposed roles are aspects of this more general function. We conclude by proposing that the dynamical systems approach, which works well in motor systems, can be extended to the rest of prefrontal cortex. Our proposed perspective will reframe outstanding questions, open up new areas of inquiry, and will align theories of prefrontal function with evolutionary principles.
Abstract: 我们提出,整个前额叶皮质从根本上来说具有运动前的性质。我们的意思是,前额叶皮质由一个动作抽象层次结构组成,其核心功能是在不同粒度级别上增强和减弱可能的动作计划。我们认为,这个层次结构的顶端应该围绕目标选择过程展开,我们认为这本质上是一种抽象的动作优化形式。解剖学和功能学证据支持这一观点,即该层次结构起源于大脑的眶面,并向背侧延伸至运动皮质。因此,我们的观点将眶额叶皮质定位为目标选择策略优化的核心部位,并暗示其他提出的角色是这一更普遍功能的方面。最后,我们提议可以将动力系统方法扩展到前额叶皮质的其余部分,这种方法在运动系统中表现良好。我们提出的视角将重新定义悬而未决的问题,开辟新的研究领域,并使前额叶功能理论与进化原则相一致。
Comments: 1 figure
Subjects: Neurons and Cognition (q-bio.NC)
Cite as: arXiv:2106.04651 [q-bio.NC]
  (or arXiv:2106.04651v1 [q-bio.NC] for this version)
  https://doi.org/10.48550/arXiv.2106.04651
arXiv-issued DOI via DataCite

Submission history

From: Benjamin Hayden [view email]
[v1] Tue, 8 Jun 2021 19:29:05 UTC (284 KB)
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