Title: Simulating NEMA characteristics of the modular total-body J-PET scanner -- an economic total-body PET from plastic scintillators Show Chinese title

Title: 模拟模块化全身J-PET扫描仪的NEMA特性——一种来自塑料闪烁体的经济型全身PET

Abstract: The purpose of the presented research is estimation of the performance characteristics of the economic Total-Body Jagiellonian-PET system (TB-J-PET) constructed from plastic scintillators. The characteristics are estimated according to the NEMA NU-2-2018 standards utilizing the GATE package. The simulated detector consists of 24 modules, each built out of 32 plastic scintillator strips (each with cross section of 6 mm times 30 mm and length of 140 cm or 200 cm) arranged in two layers in regular 24-sided polygon circumscribing a circle with the diameter of 78.6 cm. For the TB-J-PET with an axial field-of-view (AFOV) of 200 cm, a spatial resolutions of 3.7 mm (transversal) and 4.9 mm (axial) are achieved. The NECR peak of 630 kcps is expected at 30 kBq/cc activity concentration and the sensitivity at the center amounts to 38 cps/kBq. The SF is estimated to 36.2 %. The values of SF and spatial resolution are comparable to those obtained for the state-of-the-art clinical PET scanners and the first total-body tomographs: uExplorer and PennPET. With respect to the standard PET systems with AFOV in the range from 16 cm to 26 cm, the TB-J-PET is characterized by an increase in NECR approximately by factor of 4 and by the increase of the whole-body sensitivity by factor of 12.6 to 38. The TOF resolution for the TB-J-PET is expected to be at the level of CRT=240 ps (FWHM). For the TB-J-PET with an axial field-of-view (AFOV) of 140 cm, an image quality of the reconstructed images of a NEMA IEC phantom was presented with a contrast recovery coefficient (CRC) and a background variability parameters. The increase of the whole-body sensitivity and NECR estimated for the TB-J-PET with respect to current commercial PET systems makes the TB-J-PET a promising cost-effective solution for the broad clinical applications of total-body PET scanners. Show Chinese abstract

Abstract: 本研究的目的是估计由塑料闪烁体构建的经济型全身雅盖隆PET系统（TB-J-PET）的性能特征。 这些特征是根据NEMA NU-2-2018标准，利用GATE软件包进行估计的。 模拟探测器由24个模块组成，每个模块由32条塑料闪烁体条带（每条横截面为6毫米乘30毫米，长度为140厘米或200厘米）构成，以两层排列在一个正24边形中，该正多边形外接一个直径为78.6厘米的圆。 对于轴向视野（AFOV）为200厘米的TB-J-PET，实现了3.7毫米（横向）和4.9毫米（轴向）的空间分辨率。 预计在30 kBq/cc的活性浓度下，NECR峰值为630 kcps，中心灵敏度为38 cps/kBq。 SF估计为36.2%。 SF和空间分辨率的值与最先进的临床PET扫描仪以及第一代全身断层扫描仪：uExplorer和PennPET所获得的值相当。 与轴向视野（AFOV）范围从16厘米到26厘米的标准PET系统相比，TB-J-PET的NECR大约提高了4倍，整体身体灵敏度提高了12.6到38倍。 对于TB-J-PET，TOF分辨率预计将达到CRT=240 ps（FWHM）的水平。 对于轴向视野（AFOV）为140厘米的TB-J-PET，展示了NEMA IEC幻模重建图像的图像质量，包括对比度恢复系数（CRC）和背景变化参数。 与当前商业PET系统相比，对TB-J-PET估算的整体身体灵敏度和NECR的提高，使TB-J-PET成为一种具有前景的低成本有效解决方案，适用于全身PET扫描仪的广泛临床应用。