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Physics > Medical Physics

arXiv:2107.02902 (physics)
[Submitted on 4 Jul 2021 ]

Title: Monitoring and Control System Development and Experimental Validation for a Novel Extrapulmonary Respiratory Support Setup

Title: 监测与控制系统开发及新型体外呼吸支持装置的实验验证

Authors:Mahsa Doosthosseini, Kevin R. Aroom, Majid Aroom, Melissa Culligan, Warren Naselsky, Chandrasekhar Thamire, Henry W. Haslach Jr., Stephen A. Roller, James Richard Hughen, Joseph S. Friedberg, Jin-Oh Hahn, Hosam K. Fathy
Abstract: This paper presents a novel mechatronic setup intended for providing respiratory support to patients suffering from pulmonary failure. The setup relies upon the circulation of an oxygenated perfluorocarbon (PFC) through the abdominal cavity. Such circulation provides a potential pathway for the transport of oxygen to the bloodstream. However, the viability of this technology for $CO_2$ clearance has not been established. Moreover, there is a lack of experimental data enabling the modeling and identification of the underlying dynamics of this technology. To address these gaps, we develop a flexible experimental perfusion setup capable of monitoring and controlling key variables such as perfusate flowrate, temperature, pressure, and oxygenation. The paper (i) briefly summarizes the design of this setup; (ii) highlights the degree to which its data acquisition system enables the collection and cross-correlation of both perfusion-related and physiological variables; and (iii) discusses the development of flow, pressure, and temperature control algorithms for the setup. Experiments with large animals (swine) show that the setup is capable of successfully controlling the perfusion process, as well as gathering extensive data to support subsequent modeling and identification studies.
Abstract: 本文介绍了一种新颖的机电装置,旨在为患有肺功能衰竭的患者提供呼吸支持。 该装置依赖于通过腹腔循环的氧合全氟碳化合物(PFC)。 这种循环为氧气向血液的运输提供了一条潜在途径。 然而,该技术在$CO_2$清除方面的可行性尚未得到证实。 此外,缺乏实验数据以实现对该技术基本动态的建模和识别。 为解决这些差距,我们开发了一个灵活的实验灌注装置,能够监测和控制灌注液流量、温度、压力和氧合等关键变量。 本文(i)简要总结了该装置的设计;(ii)强调其数据采集系统在收集和交叉相关灌注相关和生理变量方面的程度;以及(iii)讨论了该装置的流量、压力和温度控制算法的开发。 与大型动物(猪)进行的实验表明,该装置能够成功控制灌注过程,并收集大量数据以支持后续的建模和识别研究。
Comments: 11 pages, 15 figures
Subjects: Medical Physics (physics.med-ph) ; Systems and Control (eess.SY)
Cite as: arXiv:2107.02902 [physics.med-ph]
  (or arXiv:2107.02902v1 [physics.med-ph] for this version)
  https://doi.org/10.48550/arXiv.2107.02902
arXiv-issued DOI via DataCite

Submission history

From: Mahsa Doosthosseini [view email]
[v1] Sun, 4 Jul 2021 18:03:31 UTC (6,294 KB)
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