Title: Engineered Zwitterion-Infused Clay Composites with Antibacterial and Antifungal Efficacy Show Chinese title

Title: 工程化的两性离子浸润粘土复合材料及其抗菌和抗真菌功效

Abstract: Microbes and pathogens play a detrimental role in healing wounds, causing infections like impetigo through bodily fluids and skin and entering the bloodstream through the wounds, thereby hindering the healing process and tissue regeneration. Clay, known for its long history of natural therapeutic use, has emerged as one of the most promising candidates for biomedical applications due to its non-toxic nature, porosity, high surface area, ubiquity, and excellent cation exchange capacity. This study demonstrates an innovative approach to engineering an organo-functionalized, infection-resistant, easy-to-use bandage material from clay, an environmentally benign and sustainable material. The hybrid membranes have been developed using clays, zwitterions, silver ions, and terbinafine hydrochloride (TBH) to impart antibacterial and antifungal efficacy. A critical aspect of this study is embedding organic molecules and metal ions with the clays and releasing them to resist the growth and kill the pathogens. The antimicrobial efficacy of the membranes has been tested using a zone of inhibition study against the most common microbes in skin wounds, viz. S. aureus, E. coli, and C. albicans. Results from our studies not only demonstrate the potential of these hybrid clay membranes as a cost-effective, scalable, and effective solution for treating microbial infections but also instill newer avenues for point-of-care wound-healing treatments, offering hope for improved patient outcomes. Show Chinese abstract

Abstract: 微生物和病原体在伤口愈合过程中起着有害作用，通过体液和皮肤导致感染，如脓疱病，并通过伤口进入血液，从而阻碍愈合过程和组织再生。 黏土因其悠久的天然治疗用途历史而闻名，由于其无毒、多孔、高比表面积、普遍存在以及优异的阳离子交换能力，已成为最具前景的生物医学应用候选材料之一。 本研究展示了一种创新的方法，即从黏土这种环境友好且可持续的材料中开发一种有机功能化、抗感染且易于使用的绷带材料。 这些杂化膜使用了黏土、两性离子、银离子和特比萘芬盐酸盐（TBH），以赋予其抗菌和抗真菌功效。 本研究的一个关键方面是将有机分子和金属离子嵌入黏土中，并释放出来以抵抗病原体的生长和杀灭它们。 这些膜的抗菌功效通过抑制圈实验进行了测试，针对皮肤伤口中最常见的微生物，即金黄色葡萄球菌、大肠杆菌和白色念珠菌。 我们的研究结果不仅展示了这些杂化黏土膜作为一种成本效益高、可扩展且有效的解决方案来治疗微生物感染的潜力，还为点位护理伤口愈合治疗开辟了新的途径，为改善患者预后带来了希望。