Statistics > Applications
[Submitted on 14 Jun 2025
]
Title: Kernel Density Balancing
Title: 核密度平衡
Abstract: High-throughput chromatin conformation capture (Hi-C) data provide insights into the 3D structure of chromosomes, with normalization being a crucial pre-processing step. A common technique for normalization is matrix balancing, which rescales rows and columns of a Hi-C matrix to equalize their sums. Despite its popularity and convenience, matrix balancing lacks statistical justification. In this paper, we introduce a statistical model to analyze matrix balancing methods and propose a kernel-based estimator that leverages spatial structure. Under mild assumptions, we demonstrate that the kernel-based method is consistent, converges faster, and is more robust to data sparsity compared to existing approaches.
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