Title: Multimodal near-infrared spectroscopy for biosensing applications Show Chinese title

Title: 多模态近红外光谱用于生物传感应用

Abstract: The near infrared (NIR) region of the electromagnetic spectrum contains valuable information about vibrational overtone and combination modes. Additionally, fluorophores that emit in the NIR are desired because this spectral range falls into the tissue transparency window. However, NIR techniques are not as widespread as their counterparts in the visible range because detectors, microscopes and fluorophores are less available. Here, we present a NIR multimodal and low footprint spectroscopy (NIR-MMS) setup. The setup excites NIR fluorescence using a LED or uses broadband NIR light to capture absorption spectra in the range from 900 nm to 1650 nm with a fiber-coupled InGaAs spectrograph. We demonstrate the measurement of NIR fluorescent materials and biosensors for the neurotransmitter dopamine. Additionally, the setup allows to simultaneously measure absorption and emission spectra to assess chemical changes in NIR fluorescent carbon nanotubes. Overall, this small footprint setup provides simultaneous access to NIR fluorescence and absorption spectra with broad applications in biosensing. Show Chinese abstract

Abstract: 近红外（NIR）电磁波谱区域包含关于振动倍频和组合模式的有价值信息。 此外，发射在近红外范围的荧光团是理想的，因为这个光谱范围处于组织透明窗口内。 然而，NIR技术不如可见光范围的技术广泛应用，因为检测器、显微镜和荧光团较少见。 在这里，我们介绍一种近红外多模态且占地小的光谱仪（NIR-MMS）装置。 该装置使用LED激发近红外荧光，或使用宽带近红外光，通过光纤耦合的InGaAs光谱仪在900纳米至1650纳米的范围内捕获吸收光谱。 我们展示了对近红外荧光材料和多巴胺神经递质生物传感器的测量。 此外，该装置可以同时测量吸收和发射光谱，以评估近红外荧光碳纳米管中的化学变化。 总体而言，这种占地小的装置提供了对近红外荧光和吸收光谱的同步访问，在生物传感领域具有广泛的应用。