Title: Meta-optical Miniscope for Multifunctional Imaging Show Chinese title

Title: 元光学微型显微镜用于多功能成像

Abstract: Miniaturized microscopes (miniscopes) have opened a new frontier in animal behavior studies, enabling real-time imaging of neuron activity while leaving animals largely unconstrained. Canonical designs typically use Gradient-Index (GRIN) lenses or refractive lenses as the objective module for excitation and fluorescence collection, but GRIN lenses suffer from aberrations and refractive lenses are bulky and complex. Meta-optics, composed of subwavelength diffractive elements, offer a promising alternative by combining multiple functionalities with significantly reduced footprint and weight. Here, we present meta-optical miniscopes that integrate functionalities including large field of view (FOV), extended depth of focus (EDOF), and depth sensitivity. These meta-optics replace the traditional refractive lens assembly, reducing the total track length of the objective module from 6.7 mm to 2.5 mm while enhancing imaging performance. Our results demonstrate that meta-optical miniscopes can expand the miniscope toolbox and facilitate the development of more compact and multifunctional imaging systems. Show Chinese abstract

Abstract: 微型显微镜（迷你显微镜）在动物行为研究中开辟了一个新领域，使在不显著限制动物活动的情况下实时成像神经元活动成为可能。 典型设计通常使用梯度折射率（GRIN）透镜或折射透镜作为物镜模块用于激发和荧光收集，但GRIN透镜存在像差，而折射透镜则体积大且结构复杂。 超材料光学由亚波长衍射元件组成，通过显著减小占地面积和重量，结合多种功能，提供了一个有前景的替代方案。 在此，我们介绍了集成多种功能的超材料光学迷你显微镜，包括大视场（FOV）、扩展焦深（EDOF）和深度灵敏度。 这些超材料光学元件取代了传统的折射透镜组件，将物镜模块的总轨道长度从6.7毫米减少到2.5毫米，同时提升了成像性能。 我们的结果表明，超材料光学迷你显微镜可以扩展迷你显微镜工具箱，并促进更紧凑和多功能成像系统的发展。