标题： 涂层和聚集状态在氧化铁纳米颗粒与3T3成纤维细胞相互作用中的作用 显示英文标题

标题： The role of the coating and aggregation state in the interactions between iron oxide nanoparticles and 3T3 fibroblasts

摘要： 最近的纳米毒性研究显示，工程纳米材料的物理化学特性在与活细胞的相互作用中起着重要作用。 在这里，我们报告了铁氧化物亚10纳米纳米颗粒对NIH/3T3小鼠成纤维细胞的毒性和摄入情况。 包覆策略包括低分子量配体（柠檬酸）和聚合物（聚丙烯酸，分子量 = 2000 g mol-1）。 我们发现大多数粒子具有生物相容性，因为暴露的细胞相对于对照组保持100%的存活率。 柠檬酸包覆粒子表现出强烈的摄入，这与细胞培养基中分散体的不稳定化及其沉降到细胞膜有关。 显示英文摘要

摘要： Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity and uptake of the iron oxide sub-10 nm nanoparticles by NIH/3T3 mouse fibroblasts. Coating strategies include low-molecular weight ligands (citric acid) and polymers (poly(acrylic acid), MW = 2000 g mol-1). We find that most particles were biocompatible, as exposed cells remained 100% viable relative to controls. The strong uptake shown by the citrate-coated particles is related to the destabilization of the dispersions in the cell culture medium and their sedimentation down to the cell membranes.