标题： 评估视神经头体内特定受试者的机械建模，以对眼部力学进行稳健评估 显示英文标题

标题： Evaluation of In Vivo Subject-Specific Mechanical Modeling of the Optic Nerve Head for Robust Assessment of Ocular Mechanics

摘要： 为了建立准确表示视神经头（ONH）力学的组织区域，使用了2个健康受试者的ONH影像数据来创建考虑所有主要眼部组织不同特性的活体个体化眼球机械模型。 进行了测试以评估材料属性和这些组织的包含对筛板（LC）、视网膜和视神经力学的影响。 然后，评估了由于眼内压和颅内压变化导致的筛板力学响应，以验证建模方法。 巩膜硬度对LC、视网膜和视神经的力学影响最大，而Bruch膜对这些组织的响应影响甚微。 验证测试显示压力增加时LC应变增大，并且在下部和颞部亚区的应变最高，这与文献研究一致。 因此，通过仅包括被认为是必要的那些组织区域，可以准确表示ONH的力学特性。 显示英文摘要

摘要： To establish the tissue regions necessary to accurately represent the mechanics of the optic nerve head (ONH), imaging data of the ONH from 2 healthy subjects were used to create in vivo subject-specific eye mechanical models considering distinct properties for all major ocular tissues. Tests were performed to evaluate the effect of the material properties and the inclusion of these tissues on the mechanics of the lamina cribrosa (LC), retina, and optic nerve. Then, the LC mechanical response due to variations in intraocular and intracranial pressures was evaluated to validate the modeling approach. The sclera stiffness has the largest impact on the mechanics of the LC, retina, and optic nerve, while Bruchs membrane has a negligible effect on these tissues response. The validation tests showed increased LC strain with increased pressure and highest strains in the inferior and temporal subregion, as seen in literature studies. Consequently, accurate ONH mechanical representation can be obtained by only including those tissue regions identified as necessary.