标题： 大脑神经网络中计算的多生物物理特性 显示英文标题

标题： The Multi-biophysical nature of Computation in brain neural networks

摘要： 理解动作电位的性质是理解神经系统功能的基础。 枪乌贼巨大轴突中动作电位的离子机制最早由霍奇金和赫胥黎于1952年描述，他们的发现形成了我们对生理动作电位如何运作的传统观点。 然而，现在已有大量证据表明，动作电位伴随着细胞膜中的同步耦合孤立子压力脉冲，即动作电位脉冲（AP-Pulse），我们最近证明这种脉冲在计算中具有基本功能。 在这里，我们探讨孤立子与已知与动作电位相关的离子机制之间的相互作用。 动作电位的计算模型通常将其描述为二进制事件，但我们已经证明，它必须是一个称为计算动作电位（CAP）的量子三进制事件，其时间固定点是孤立子的阈值，而不是其他模型中用于促进有意义计算的较为灵活的动作电位峰值。 我们详细展示了这种频率计算在视网膜中的应用，并且还为其他大脑神经网络的计算提供了广泛的分析。 CAP伴随着APPulse和生理动作电位。 因此，我们得出结论，神经冲动似乎是由三种不可分离、相互依赖、同时存在的状态组成的集合：生理动作电位、APPulse和CAP。 然而，虽然生理动作电位在神经连接方面很重要，但它与计算过程无关，因为计算总是由APPulse的孤立子部分促进的。 显示英文摘要

摘要： Comprehending the nature of action potentials is fundamental to our understanding of the functioning of nervous systems in general. The ionic mechanisms underlying action potentials in the squid giant axon were first described by Hodgkin and Huxley in 1952 and their findings have formed our orthodox view of how the physiological action potential functions. However, substan-tial evidence has now accumulated to show that the action potential is accompanied by a syn-chronized coupled soliton pressure pulse in the cell membrane, the action potential pulse (AP-Pulse) which we have recently shown to have an essential function in computation. Here we ex-plore the interactions between the soliton and the ionic mechanisms known to be associated with the action potential. Computational models of the action potential usually describe it as a binary event, but we have shown that it must be a quantum ternary event known as the computa-tional action potential (CAP), whose temporal fixed point is the threshold of the soliton, rather than the rather plastic action potential peak used in other models to facilitate meaningful compu-tation. We have demonstrated this type of frequency computation for the retina, in detail, and also provided an extensive analysis for computation for other brain neural networks. The CAP ac-companies the APPulse and the Physiological action potential. Therefore, we conclude that nerve impulses appear to be an ensemble of three inseparable, interdependent, concurrent states: the physiological action potential, the APPulse and the CAP. However, while the physio-logical action potential is important in terms of neural connectivity, it is irrelevant to computational processes as this is always facilitated by the soliton part of the APPulse.