标题： 模型化多发性骨髓瘤对肾功能的影响 显示英文标题

标题： Modeling the Effects of Multiple Myeloma on Kidney Function

摘要： 多发性骨髓瘤（MM），一种浆细胞癌，与许多健康挑战有关，包括由于肾小管间质纤维化导致的肾脏损伤。 我们开发了一个数学模型，以捕捉涉及细胞和蛋白质种群的定性行为。 具体而言，我们模拟了肾脏近端小管中的细胞、游离轻链、肾成纤维细胞和骨髓瘤细胞之间的相互作用。 我们对该模型进行稳态解分析，以找到在数学和生物学上相关且稳定的稳态解。 这个基础模型提供了对肾小管间质纤维化中关键种群之间动态关系的描述，展示了这些种群如何相互作用以影响多发性骨髓瘤和肾功能受损患者的患者预后。 显示英文摘要

摘要： Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblasts, and myeloma cells. We analyze the model for steady-state solutions to find a mathematically and biologically relevant stable steady-state solution. This foundational model provides a representation of dynamics between key populations in tubulointerstitial fibrosis that demonstrates how these populations interact to affect patient prognosis in patients with MM and renal impairment.