标题： 通过(MnZn)铁氧体-聚丙烯腈复合纳米纤维膜增强间充质干细胞反应并保持生物相容性 显示英文标题

标题： Enhanced Mesenchymal Stem Cell Response with Preserved Biocompatibility via (MnZn)Ferrite--Polyacrylonitrile Composite Nanofiber Membranes

摘要： 本研究专注于含有磁性氧化物纳米颗粒（NPs）的先进聚合物复合电纺纳米纤维（NFs）的合成与表征。 通过利用电纺丝方法，研究旨在探讨具有增强界面性能、改善双层电容和足够生物相容性的聚合物复合材料。 电纺聚丙烯腈（PAN）纳米纤维中嵌入了Fe2O3和MnZn铁氧体纳米颗粒，采用先进技术进行了全面表征，即傅里叶变换红外光谱（FTIR）、X射线光电子能谱（XPS）、高分辨率扫描电子显微镜（HR-SEM）、X射线衍射（XRD）和交替梯度场磁强计（AGFM）。 金属氧化物纳米颗粒的引入导致纳米纤维的热学、光谱和形貌特性发生显著变化。 XPS分析证实了热处理后氧化程度增加、石墨碳含量增加以及新氮功能基团的形成。 此外，观察到氰基团与金属离子之间的相互作用，表明纳米颗粒对表面化学的影响。 磁性表征显示这些复合纳米纤维具有产生磁场的潜力，可用于生物医学操控。 细胞相容性研究显示对人间质干细胞的活力或形态无显著影响，突显了其生物相容性。 这些发现表明，PAN-磁性纳米纤维在靶向药物输送、磁共振成像（MRI）和癌症治疗的磁热疗等应用中具有良好的前景。 显示英文摘要

摘要： This study focuses on the synthesis and characterization of advanced polymeric composite electrospun nanofibers (NFs) containing magnetic oxide nanoparticles (NPs). By leveraging the method of electrospinning, the research aims to investigate polymer composites with enhanced interfacial properties, improved double-layer capacitance, and adequate biocompatibility. Electrospun polyacrylonitrile (PAN) NFs embedded with Fe2O3 and MnZn ferrite NPs were comprehensively characterized using advanced techniques, i.e., Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), high-resolution scanning electron microscopy (HR-SEM), X-ray diffraction (XRD), and alternating gradient field magnetometry (AGFM). The incorporation of metal oxide NPs led to significant changes in the thermal, spectroscopic, and morphological properties of the NFs. XPS analysis confirmed increased oxidation, graphitic carbon content, and the formation of new nitrogen functionalities after heat treatment. Furthermore, interactions between nitrile groups and metal ions were observed, indicating the influence of nanoparticles on surface chemistry. Magnetic characterization demonstrated the potential of these composite NFs to generate magnetic fields for biomedical manipulation. Cytocompatibility studies revealed no significant impact on the viability or morphology of human mesenchymal stromal cells, highlighting their biocompatibility. These findings suggest the promising use of PAN-magnetic NFs in applications including targeted drug administration, magnetic resonance imaging (MRI), and magnetic hyperthermia for cancer treatment.