标题： 分子信息传递中的外在和内在相关性 显示英文标题

标题： Extrinsic and intrinsic correlations in molecular information transmission

摘要： 细胞通过细胞表面受体捕获配体分子来测量外部配体的浓度。 不同受体捕获的分子数量共同变化，因为它们依赖于相同的外部配体波动。 然而，由于化学过程的内在随机性，这些数量也会反向变化，因为一个受体随机捕获的分子不能被另一个受体捕获。 这种受体相关性的结构通常被认为相比于独立受体的情况，会增加对外部信号的信息量。 我们分析了一个可解的两个分子受体模型，并表明，与这种普遍期望相反，相关性对配体浓度信息的影响是微小且负面的。 此外，我们表明，对多个受体进行平均的测量几乎和跟踪每个个体受体状态的测量一样具有信息量。 显示英文摘要

摘要： Cells measure concentrations of external ligands by capturing ligand molecules with cell surface receptors. The numbers of molecules captured by different receptors co-vary because they depend on the same extrinsic ligand fluctuations. However, these numbers also counter-vary due to the intrinsic stochasticity of chemical processes because a single molecule randomly captured by a receptor cannot be captured by another. Such structure of receptor correlations is generally believed to lead to an increase in information about the external signal compared to the case of independent receptors. We analyze a solvable model of two molecular receptors and show that, contrary to this widespread expectation, the correlations have a small and negative effect on the information about the ligand concentration. Further, we show that measurements that average over multiple receptors are almost as informative as those that track the states of every individual one.