标题： 发育基因调控的空间和时间尺度的桥梁 显示英文标题

标题： Bridging spatial and temporal scales of developmental gene regulation

摘要： 多细胞生物的发育依赖于在多个空间和时间尺度上分子事件的精确协调。 了解在发育过程中信息如何从分子相互作用流向细胞过程和组织结构对于解释复杂生物体的显著可重复性至关重要。 本综述探讨了染色质编码的信息如何从局部转录事件传递到全局基因表达模式，并强调了弥合这些尺度的挑战。 我们讨论了最近的实验发现和理论框架，强调聚合物物理作为描述染色质结构和动力学跨尺度关系的工具。 通过整合这些观点，我们旨在阐明基因调控如何在生物组织的不同层次上协调，并提出未来实验方法的策略。 显示英文摘要

摘要： The development of multicellular organisms relies on the precise coordination of molecular events across multiple spatial and temporal scales. Understanding how information flows from molecular interactions to cellular processes and tissue organization during development is crucial for explaining the remarkable reproducibility of complex organisms. This review explores how chromatin-encoded information is transduced from localized transcriptional events to global gene expression patterns, highlighting the challenge of bridging these scales. We discuss recent experimental findings and theoretical frameworks, emphasizing polymer physics as a tool for describing the relationship between chromatin structure and dynamics across scales. By integrating these perspectives, we aim to clarify how gene regulation is coordinated across levels of biological organization and suggest strategies for future experimental approaches.