标题： 干细胞：好的、坏的和丑的 显示英文标题

标题： Stem Cells: The Good, the Bad and the Ugly

摘要： 癌症干细胞由发育网络控制，这些网络通常在拓扑结构上与正常的健康干细胞无法区分。 问题是为什么癌症干细胞既可以表型不同，又在形态学上与正常干细胞有如此大的差异。 癌症干细胞与正常干细胞之间的差异并不在于它们的网络结构差异，而在于其在基因组中的时空激活局部性以及由此在体内产生的表达结果。 转移潜力癌症干细胞的主要依据并不是它们与正常干细胞的网络分歧，而是基于非网络的遗传变化，这些变化使得细胞能够进化出基于基因的表型特性，从而实现其逃逸并转移到身体其他部位。 干细胞网络理论允许精确预测干细胞行为动力学，并对正常和癌症干细胞的增殖进行数学描述。 它表明，最佳的治疗方法是首先针对最高阶的干细胞，否则所谓的治愈癌症的自发缓解总是存在危险。 干细胞网络指出了诊断和治疗不仅限于干细胞癌症，而且一般癌症的新方法的路径。 显示英文摘要

摘要： Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different from normal stem cells. The difference between cancer stem cells and normal stem cells lies not in differences their network architecture, but rather in the spatial-temporal locality of their activation in the genome and the resulting expression in the body. The metastatic potential cancer stem cells is not based primarily on their network divergence from normal stem cells, but on non-network based genetic changes that enable the evolution of gene-based phenotypic properties of the cell that permit its escape and travel to other parts of the body. Stem cell network theory allows the precise prediction of stem cell behavioral dynamics and a mathematical description of stem cell proliferation for both normal and cancer stem cells. It indicates that the best therapeutic approach is to tackle the highest order stem cells first, otherwise spontaneous remission of so called cured cancers will always be a danger. Stem cell networks point to a pathway to new methods to diagnose and cure not only stem cell cancers but cancers generally.