标题： 早期耳聋会导致听觉皮层以外的全局功能连接的重塑 显示英文标题

标题： Early deafness leads to re-shaping of global functional connectivity beyond the auditory cortex

摘要： 早期的感觉剥夺，如失明或失聪，以多种方式塑造大脑发育。 虽然已经确定被剥夺的大脑区域开始参与剩余模态的刺激处理和高级认知任务，但一些报告还表明非剥夺大脑区域可能存在结构和功能变化。 我们通过检查全局网络分离和整合来比较早发性聋成人和听力对照组的大脑静息状态功能网络组织。 与听力对照组相比，聋成人表现出模块化组织的改变，显著性网络的区域与额顶叶网络耦合。 他们表现出听觉和躯体运动区域之间的连接较弱，额顶叶网络与其他几个大规模网络（视觉、记忆、扣带-岛盖和躯体运动）之间的耦合较强，并且默认模式网络扩大。 他们的整体功能分离度也较低。 我们的研究结果表明，聋成人的大脑可塑性不仅限于听觉皮层的变化，还改变了其他大规模网络之间的耦合。 这些广泛的功能连接变化可能为聋人在视觉和注意任务中的优越行为表现提供一种机制。 显示英文摘要

摘要： Early sensory deprivation such as blindness or deafness shapes brain development in multiple ways. While it is established that deprived brain areas start to be engaged in the processing of stimuli from the remaining modalities and in high-level cognitive tasks, some reports have also suggested the possibility of structural and functional changes in non-deprived brain areas. We compared resting-state functional network organization of the brain in early-deaf adults and hearing controls by examining global network segregation and integration. Relative to hearing controls, deaf adults exhibited an altered modular organization, with regions of the salience network coupled with the fronto-parietal network. They showed weaker connections between auditory and somatomotor regions, stronger coupling between the fronto-parietal network and several other large-scale networks (visual, memory, cingulo-opercular and somatomotor), and an enlargement of the default mode network. Their overall functional segregation of brain networks was also lower. Our findings suggest that brain plasticity in deaf adults is not limited to changes in auditory cortex but additionally alters the coupling between other large-scale networks. These widespread functional connectivity changes may provide a mechanism for the superior behavioral performance of the deaf in visual and attentional tasks.