标题： 物种间代谢物分布的全局架构及其形成机制 显示英文标题

标题： Global architecture of metabolite distributions across species and its formation mechanisms

摘要： 生物体通过其代谢产生多种类型的代谢物。 特别是，植物种类的类黄酮是一种次级代谢物，是有趣的例子。 由于认为植物种类具有与多样化环境相关的特定类黄酮，阐明代谢物在植物种类间的分布设计原则对于理解代谢物多样性和植物进化非常重要。 在之前的工作中，我们发现了代谢物分布中的异质连接性，并提出一个简单模型来解释异质连接性的可能起源。 在本文中，我们展示了受植物-动物互利网络类比启发的代谢物分布家族中的进一步结构特性：嵌套结构和模块化结构。 一个早期模型表示，这些双部关系中的结构特性是基于元素的特征和外部因素确定的。 然而，通过将我们的模型与早期模型进行比较，我们发现代谢物分布的结构可以通过简单的进化过程来描述，而无需基于特征的机制。 除了定性和定量地更好地预测异质连接性外，我们的模型还能更好地预测嵌套结构和模块化结构。 这一发现暗示了这些结构特性的另一种可能的起源，并表明植物种类间代谢物分布的形成机制比预期的更简单。 显示英文摘要

摘要： Living organisms produce metabolites of many types via their metabolisms. Especially, flavonoids, a kind of secondary metabolites, of plant species are interesting examples. Since plant species are believed to have specific flavonoids with respect to diverse environment, elucidation of design principles of metabolite distributions across plant species is important to understand metabolite diversity and plant evolution. In the previous work, we found heterogeneous connectivity in metabolite distributions, and proposed a simple model to explain a possible origin of heterogeneous connectivity. In this paper, we show further structural properties in the metabolite distribution among families inspired by analogy with plant-animal mutualistic networks: nested structure and modular structure. An earlier model represents that these structural properties in bipartite relationships are determined based on traits of elements and external factors. However, we find that the architecture of metabolite distributions is described by simple evolution processes without trait-based mechanisms by comparison between our model and the earlier model. Our model can better predict nested structure and modular structure in addition to heterogeneous connectivity both qualitatively and quantitatively. This finding implies an alternative possible origin of these structural properties, and suggests simpler formation mechanisms of metabolite distributions across plant species than expected.