标题： 小鼠表皮维持的机制：细胞分裂与投票者模型 显示英文标题

标题： Mechanism of murine epidermal maintenance: Cell division and the Voter Model

摘要： 本文介绍了一个有趣的生物领域中选民模型统计的实验例子。 在最近关于小鼠尾部皮肤的研究中，我们发现增殖细胞被限制在一个二维层内时，细胞会根据一种简单的随机细胞分裂模型进行增殖和分化，该模型只涉及一种类型的增殖细胞，这种细胞可以进行对称和不对称分裂。 有趣的是，这些简单的规则在无需考虑细胞空间分布的情况下就能很好地预测细胞群体动力学。 然而，如果通过允许细胞随机扩散来研究细胞的空间行为，则可以推断出密度波动会破坏组织的连续性，这表明物理系统中存在某种隐含的空间调控机制。 为了推断空间调控的机制，我们考虑了一种保留总体群体动态的二维细胞命运模型。 通过将这种模型的行为与“选民”模型的三物种变体联系起来，我们预测基底层的增殖细胞应该形成簇。 对用增殖活性染色的细胞的相关经验关联分析证实了自然界中确实观察到了预期的聚类行为。 显示英文摘要

摘要： This paper presents an interesting experimental example of voter-model statistics in biology. In recent work on mouse tail-skin, where proliferating cells are confined to a two-dimensional layer, we showed that cells proliferate and differentiate according to a simple stochastic model of cell division involving just one type of proliferating cell that may divide both symmetrically and asymmetrically. Curiously, these simple rules provide excellent predictions of the cell population dynamics without having to address their spatial distribution. Yet, if the spatial behaviour of cells is addressed by allowing cells to diffuse at random, one deduces that density fluctuations destroy tissue confluence, implying some hidden degree of spatial regulation in the physical system. To infer the mechanism of spatial regulation, we consider a two-dimensional model of cell fate that preserves the overall population dynamics. By identifying the resulting behaviour with a three-species variation of the "Voter" model, we predict that proliferating cells in the basal layer should cluster. Analysis of empirical correlations of cells stained for proliferation activity confirms that the expected clustering behaviour is indeed seen in nature.