标题： 细胞骨架诱导的脂质膜泡状变形的计算机模拟 显示英文标题

标题： Computer Simulation of Cytoskeleton-Induced Blebbing in Lipid Membranes

摘要： 细胞膜突起是在许多生理过程中形成的气球状膜突出结构。 通过计算机模拟一种与弹性网状结构耦合的自组装脂质双层粒子模型，我们研究了细胞膜突起的相行为和动力学。 我们发现，当双层膜和细胞骨架的面积比值较大时，会形成细胞膜突起。 我们还发现，当细胞骨架受到局部消融或均匀压缩时，可以诱导细胞膜突起。 所得结果在定性上与实验证据一致，该模型为详细研究细胞膜突起的形成动力学提供了可能性。 显示英文摘要

摘要： Blebs are balloon-shaped membrane protrusions that form during many physiological processes. Using computer simulation of a particle-based model for self-assembled lipid bilayers coupled to an elastic meshwork, we investigated the phase behavior and kinetics of blebbing. We found that blebs form for large values of the ratio between the areas of the bilayer and the cytoskeleton. We also found that blebbing can be induced when the cytoskeleton is subject to a localized ablation or a uniform compression. The results obtained are qualitatively in agreement with the experimental evidence and the model opens up the possibility to study the kinetics of bleb formation in detail.