标题： 疟疾色素晶体作为磁性微转子：高灵敏度诊断的关键 显示英文标题

标题： Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis

摘要： 开发高灵敏度疟疾诊断新方法的需要已引发了医学和跨学科科学领域的全球活动。 大多数新兴技术种类繁多，均基于研究级仪器、复杂的基于试剂的检测方法或依赖专业知识。 在此，我们提出了一种替代性的光学方法，其具有易于使用且成本效益高的设备，该设备基于之前报道的疟疾色素的独特特性，并在本研究中进行了定量确定。 疟疾色素，也称为血红素，是血红素的不溶性微晶形式。 这些晶体表现出显著的磁性和光学各向异性，与血液中的任何其他成分明显不同。 因此，它们可以同时作为磁驱动的微转子和旋转偏振器在悬浮液中起作用。 这些特性不仅在疟疾诊断和治疗中具有重要意义，其中血红素被认为是一种药物靶点或免疫调节剂，而且在微观尺度上对细胞和组织的磁操控也具有重要意义。 显示英文摘要

摘要： The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse variety of emerging techniques are based on research-grade instruments, sophisticated reagent-based assays or rely on expertise. Here, we suggest an alternative optical methodology with an easy-to-use and cost-effective instrumentation based on unique properties of malaria pigment reported previously and determined quantitatively in the present study. Malaria pigment, also called hemozoin, is an insoluble microcrystalline form of heme. These crystallites show remarkable magnetic and optical anisotropy distinctly from any other components of blood. As a consequence, they can simultaneously act as magnetically driven micro-rotors and spinning polarizers in suspensions. These properties can gain importance not only in malaria diagnosis and therapies, where hemozoin is considered as drug target or immune modulator, but also in the magnetic manipulation of cells and tissues on the microscopic scale.