标题： 通过光机械耦合监测微管机械振动 显示英文标题

标题： Monitoring Microtubule Mechanical Vibrations via Optomechanical Coupling

摘要： 在有丝分裂期间，微管可能受到干扰，从而控制癌细胞的复制。 可以通过外部场（例如电磁场或超声波）检测和控制细胞内微管的机械振荡，从而实现癌症的检测和治疗。 然而，关于微管的动态（高频）机械特性了解甚少。 在此，我们提出通过探针电极控制双端夹持微管的振动，并通过微管振动模式与光学腔之间的光机械耦合来检测其运动。 在存在红失谐强泵浦激光的情况下，这种耦合会导致光学探测场的光机械诱导透明，这可以使用最先进的技术进行检测。 透明峰的中心频率和带宽分别给出了微管的共振频率和阻尼率，而峰的高度则揭示了微管-腔场耦合的信息。 我们的方法应能提供有关微管物理特性的新知识，这将增强我们设计物理癌症治疗方案的能力，作为化疗药物的替代方案。 显示英文摘要

摘要： The possible disruption of a microtubule during mitosis can control the duplication of a cancer cell. Cancer detection and treatment may be possible based on the detection and control of microtubule mechanical oscillations in cells through external fields (e.g. electromagnetic or ultrasound). However, little is known about the dynamic (high-frequency) mechanical properties of microtubules. Here we propose to control the vibrations of a doubly clamped microtubule by tip electrodes and to detect its motion via the optomechanical coupling between the vibrational modes of the microtubule and an optical cavity. In the presence of a red-detuned strong pump laser, this coupling leads to optomechanical induced transparency of an optical probe field, which can be detected with state-of the art technology. The center frequency and linewidth of the transparency peak give the resonance frequency and damping rate of the microtubule respectively, while the height of the peak reveals information about the microtubule-cavity field coupling. Our method should yield new knowledge about the physical properties of microtubules, which will enhance our capability to design physical cancer treatment protocols as alternatives to chemotherapeutic drugs.