标题： 傅里叶全息显微镜的系统校准方法 显示英文标题

标题： System calibration method for Fourier ptychographic microscopy

摘要： 傅里叶相位光学显微镜（FPM）是一种最近提出的具有高分辨率和宽视场（FOV）的定量相位成像技术。 在当前的FPM成像平台中，系统误差源来自像差、LED强度波动、参数不完善和噪声，这些都会严重破坏重建结果并产生伪影。 尽管这些问题已经被研究，并分别提出了一些特殊方法，但还没有一种方法可以解决所有问题。 然而，在实际情况中，系统误差是各种来源的混合体。 由于类似的伪影，很难区分一种误差源和另一种误差源。 为此，我们报告了一种基于模拟退火（SA）算法、LED强度校正和自适应步长策略的系统校准程序，称为SC-FPM，该程序涉及在每次迭代步骤中评估一个误差矩阵，然后重新估计准确的参数。 在模拟和实验中都取得了很好的性能。 报告的系统校准方案提高了FPM的鲁棒性，放宽了实验条件，使FPM更加实用。 显示英文摘要

摘要： Fourier ptychographic microscopy (FPM) is a recently proposed quantitative phase imaging technique with high resolution and wide field-of-view (FOV). In current FPM imaging platforms, systematic error sources come from the aberrations, LED intensity fluctuation, parameter imperfections and noise, which will severely corrupt the reconstruction results with artifacts. Although these problems have been researched and some special methods have been proposed respectively, there is no method to solve all of them. However, the systematic error is a mixture of various sources in the real situation. It is difficult to distinguish a kind of error source from another due to the similar artifacts. To this end, we report a system calibration procedure, termed SC-FPM, based on the simulated annealing (SA) algorithm, LED intensity correction and adaptive step-size strategy, which involves the evaluation of an error matric at each iteration step, followed by the re-estimation of accurate parameters. The great performance has been achieved both in simulation and experiments. The reported system calibration scheme improves the robustness of FPM and relaxes the experiment conditions, which makes the FPM more pragmatic.