标题： 尿素介导的支撑脂质双层中的异常扩散 显示英文标题

标题： Urea-Mediated Anomalous Diffusion in Supported Lipid Bilayers

摘要： 生物膜中的扩散很少仅仅是布朗运动；相反，扩散速率依赖于观察的时间尺度，因此通常被描述为异常扩散。 为了更好地理解这一现象，需要模型系统，其中可以调节和量化脂质双层的异常亚扩散。 我们最近通过在支持的脂质双层（SLBs）中引入带有聚乙二醇衍生的脂质，控制排斥面积分数，展示了这样一个模型。 在此，我们扩展了这项工作，使用尿素诱导SLBs中的异常亚扩散。 通过调节孵育时间和尿素浓度，我们制备了表现出与生物膜中观察到的相同尺度异常行为的DCPC双层。 显示英文摘要

摘要： Diffusion in biological membranes is seldom simply Brownian motion; instead, the rate of diffusion is dependent on the timescale of observation and so is often described as anomalous. In order to help better understand this phenomenon, model systems are needed where the anomalous subdiffusion of the lipid bilayer can be tuned and quantified. We recently demonstrated one such model by controlling the excluded area fraction in supported lipid bilayers (SLBs) through the incorporation of lipids derivatised with polyethylene glycol. Here we extend this work, using urea to induce anomalous subdiffusion in SLBs. By tuning incubation time and urea concentration, we produce DCPC bilayers that exhibit anomalous behaviour on the same scale observed in biological membranes.