标题： 结构对称性和膜曲率感知 显示英文标题

标题： Structural symmetry and membrane curvature sensing

摘要： 对称性与多蛋白复合物的功能、遗传学和化学性质密切相关。 在这里，我们探讨结构对称性与膜蛋白感知和诱导膜曲率的能力之间的关系，这是调节细胞膜形状和组织的关键因素。 通过粗粒度模拟和弹性理论，我们表明方向依赖的膜曲率感知潜力仅限于不对称蛋白质、二聚体和四聚体，并认为应预期这种各向异性对于二聚体最强。 奇数次和更高阶的对称性强烈抑制方向性曲率感知。 这种分类为膜蛋白的结构-功能关系提供了新的视角，并简化了将分子感知机制与其大尺度细胞后果之间进行转换的任务。 显示英文摘要

摘要： Symmetry is closely intertwined with the function, genetics, and chemical properties of multiprotein complexes. Here, we explore the relation between structural symmetry and the ability of membrane proteins to sense and induce membrane curvature, which is a key factor for modulating the shape and organization of cell membranes. Using coarse-grained simulations and elasticity theory, we show that the potential for direction-dependent membrane curvature sensing is limited to asymmetric proteins, dimers, and tetramers, and argue that one should expect this anisotropy to be strongest for dimers. Odd and higher-order symmetries strongly suppress directional curvature sensing. This classification gives a new perspective on the structure-function relation for membrane proteins, and simplifies the task of translating between molecular sensing mechanisms and their large-scale cellular consequences.