标题： 代谢网络的灵敏度：扰动代谢物浓度 显示英文标题

标题： Sensitivity of metabolic networks: perturbing metabolite concentrations

摘要： 敏感性研究网络对扰动的响应。 我们考虑在平衡状态下代谢物浓度的局部扰动。 我们研究网络中的响应，包括代谢物浓度和反应通量。 我们的方法是纯粹定性的，而不是定量的。 事实上，我们的分析仅基于反应网络的化学计量学，不需要任何关于反应速率的定量信息。 相反，描述仅以代数形式进行，所需唯一数据是网络结构。 生物应用包括代谢控制和网络重建。 显示英文摘要

摘要： Sensitivity studies the network response to perturbations. We consider local perturbations of the concentrations of metabolites at an equilibrium. We investigate the responses in the network, both of the metabolite concentrations and of the reaction fluxes. Our approach is purely qualitative, rather than quantitative. In fact, our analysis is based, solely, on the stoichiometry of the reaction network and we do not require any quantitative information on the reaction rates. Instead, the description is done only in algebraic terms, and the only data required is the network structure. Biological applications include metabolic control and network reconstruction.