标题： 一种重新定义和广义的激活重叠百分比度量用于fMRI可重复性的研究及其在识别异常激活图中的应用 显示英文标题

标题： A Re-defined and Generalized Percent-Overlap-of-Activation Measure for Studies of fMRI Reproducibility and its Use in Identifying Outlier Activation Maps

摘要： 功能性磁共振成像~(fMRI) 是一种流行的无创方式，用于研究人脑中的激活情况。 大多数 fMRI 实验的最终结果是与给定范式相对应的激活图。 这些图在不同研究之间可能有很大差异，因此对多个 fMRI 研究中识别出的激活情况进行可靠性量化非常重要。 激活的重叠百分比~\citep{romboutsetal98,machielsenetal00}是来自任何两个 fMRI 研究的激活图之间的全局可靠性度量。 一个稍作修改但更直观的度量是由~\citet{jaccard1901}相似性系数提供的，我们在这篇论文中研究了其使用方法。 还提出了一种这些度量的推广方法，以全面总结多个 fMRI 研究的可靠性。 最后，开发了一种测试机制来标记潜在异常的研究。 该方法在涉及右利手男性受试者在两个月内多次进行左右手运动任务范式的研究所中得到展示，并取得了很好的结果。 显示英文摘要

摘要： Functional Magnetic Resonance Imaging~(fMRI) is a popular non-invasive modality to investigate activation in the human brain. The end result of most fMRI experiments is an activation map corresponding to the given paradigm. These maps can vary greatly from one study to the next, so quantifying the reliability of identified activation over several fMRI studies is important. The percent overlap of activation~\citep{romboutsetal98,machielsenetal00} is a global reliability measure between activation maps drawn from any two fMRI studies. A slightly modified but more intuitive measure is provided by the ~\citet{jaccard1901} coefficient of similarity, whose use we study in this paper. A generalization of these measures is also proposed to comprehensively summarize the reliability of multiple fMRI studies. Finally, a testing mechanism to flag potentially anomalous studies is developed. The methodology is illustrated on studies involving left- and right-hand motor task paradigms performed by a right-hand dominant male subject several times over a period of two months, with excellent results.