标题： 通用准粒子动力学控制细胞死亡决定 显示英文标题

标题： Universal quasi-particle kinetics control the cell death decision

摘要： 理解波动如何在空间尺度上传播是理解从湍流到临界现象等无生命物质的核心。与物理系统不同，生物系统被组织成在离散空间尺度上的层次化过程：它们是分隔的。在这里，我们展示了随机系统的动态分隔导致了出现类似准粒子的动力学，这些动力学被细胞用于执行关键的生物功能。具体来说，我们推导出一个一般理论，该理论预测无论系统细节如何，都会出现单一自由度。我们得到了描述其独特动力学特性的运动方程和响应。我们通过实验展示了准粒子动力学在细胞决定是否自杀（凋亡）中的生物学相关性。使用荧光显微镜，我们显示细胞对凋亡刺激的响应表现出类似准粒子的动力学，这些动力学为细胞应激信号建立了低通滤波器。通过强调细胞如何操控噪声和信号在空间尺度上的传播，我们的工作揭示了一种新的细胞命运决策机制。 显示英文摘要

摘要： Understanding how fluctuations propagate across spatial scales is central to our understanding of inanimate matter from turbulence to critical phenomena. In contrast to physical systems, biological systems are organized into a hierarchy of processes on a discrete set of spatial scales: they are compartmentalized. Here, we show that dynamic compartmentalization of stochastic systems leads to emergent, quasi-particle-like kinetics which are used by cells to perform key biological functions. Specifically, we derive a general theory that predicts the emergence of a single degree of freedom irrespective of system specifics. We obtain equations of motion and response characterising its unique kinetic properties. We experimentally demonstrate the biological relevance of quasi-particle kinetics in the decision of cells to commit suicide (apoptosis). Using fluorescent microscopy, we show that the response of cells to apoptotic stimuli exhibits quasi-particle like kinetics which establish a low-pass filter for cellular stress signals. By highlighting that cells manipulate how noise and signals propagate across spatial scales, our work reveals a new mechanism of cell fate decision-making.