标题： 锌氧化物纳米颗粒的物理化学和抗菌性能的封端剂控制 显示英文标题

标题： Capping agent control over the physicochemical and antibacterial properties of ZnO nanoparticles

摘要： 生命科学研究所很大程度上受益于纳米颗粒（NPs）的使用，然而诸如胶体稳定性和对NP尺寸和形状的控制等基本问题会影响NP在生物医学应用中的性质和功能。在这里，我们展示了将封端剂直接包含在氧化锌（ZnO）NP合成中可以更好地控制这些性质并增强其功能。本文介绍了对封端剂对使用微波（MW）辅助溶剂法合成的ZnO NP的物理化学和抗菌性质影响的系统研究。初级NP尺寸（10-20 nm）通过锌前驱体浓度进行控制，NP形状受封端剂类型的影响。封端剂使ZnO的表面电荷和水相互作用特性得以控制，以便进一步研究与细菌相关的性质。使用带正电荷、亲水性的HMTA封端的ZnO观察到了优越的抗菌效果，然而带负电荷的疏水性OA封端的ZnO仍然表现出抗菌效果。这些观察结果表明存在不同的潜在机制，我们特别参考了ZnO的比表面积及其对细菌-纳米颗粒相互作用的关键作用来讨论这些差异。选择合适的封端剂对于合成用于抗菌应用的高效ZnO NPs至关重要，特别是对抗耐药性。 显示英文摘要

摘要： Life science research has largely benefited from the use of nanoparticles (NPs), yet fundamental issues such as colloidal stability and control over NP size and shape affect NP properties and functions in biomedical applications. Here we show that including capping agents directly into zinc oxide (ZnO) NP synthesis can lead to better control of these properties and their enhanced functionality. A systematic study of the influence capping agents has on the physicochemical and antibacterial properties of ZnO NP synthesized using the microwave (MW)-assisted polyol method is presented. Primary NP size (10-20 nm) was controlled by zinc precursor concentration, and NP shape was influenced by capping agent type. Capping agents enabled control over the surface charge and water interaction properties of ZnO for further investigations involving bacteria. The superior antibacterial effect was observed using positively charged, hydrophilic HMTA-capped ZnO, yet negatively charged hydrophobic OA-capped ZnO still exhibited an antibacterial effect. These observations suggest different underlying mechanisms, and we discuss these differences with particular reference to the specific surface area of ZnO, and how this is key to bacteria-nanoparticle interactions. Appropriate selection of capping agents is crucial for the synthesis of potent ZnO NPs intended for antibacterial applications, specifically for combating resistance.