标题： 螺旋缺陷混沌伴随着间歇性增加平均终止时间 显示英文标题

标题： Spiral defect chaos with intermittency increases mean termination time

摘要： 心脏模型是可兴奋系统的一个例子，并且可以支持稳定的螺旋波。然而，对于某些参数值，这些螺旋波可能会变得不稳定，导致螺旋波缺陷混沌（SDC），其特征是螺旋波的持续生成和湮灭，并被认为与心房颤动有关。在SDC期间，螺旋波的数量波动并最终降至零，标志着活动的终止。在这项工作中，我们证明通过改变一个单一参数可以使系统从SDC过渡到单个螺旋波，经过一个间歇性动力学的中间阶段。在这个间歇性动力学中，SDC间隔被非SDC间隔夹在中间，在这些间隔中螺旋波的数量保持较小且恒定。我们量化了这种间歇性，并表明当控制参数接近使单个螺旋波稳定的状态值时，平均终止时间显著增加。此外，我们还发现，在计算域的一部分区域可能存在间歇性出现的准稳态螺旋波，而其余部分则表现出SDC。我们的结果可能对临床心房颤动具有意义，后者通常表现出间歇性，即在心房颤动和正常窦性心律之间来回切换。 显示英文摘要

摘要： Cardiac models are examples of excitable systems and can support stable spiral waves. For certain parameter values, however, these spiral waves can become unstable, resulting in spiral defect chaos (SDC), characterized by the continuous creation and annihilation of spiral waves and thought to underlie atrial fibrillation. During SDC, the number of spiral waves fluctuates and eventually drops to zero, marking the termination of activity. In this work, we demonstrate that varying a single parameter allows the system to transition from SDC to a single spiral wave, passing through an intermediate regime of intermittency. In this intermittent dynamics, intervals of SDC are sandwiched between non-SDC intervals during which the number of spiral waves remains small and constant. We quantify this intermittency and show that the mean termination time increases significantly as the control parameter approaches values for which a single spiral wave is stable. In addition, we find that it is also possible to have intermittently present quasi-stable spiral waves in part of the computational domain while the remainder of the domain exhibits SDC. Our results may have implications for clinical atrial fibrillation, which often shows intermittency, switching back-and-forth between fibrillation and normal sinus rhythm.