标题： 轻度认知障碍患者在干扰抑制过程中注意网络的效率降低 显示英文标题

标题： Reduced Efficiency in the Attentional Network During Distractor Suppression in Mild Cognitive Impairment

摘要： 轻度认知障碍（MCI）是正常认知老化与痴呆之间的关键过渡阶段，因此早期检测至关重要。 本研究利用注意力提示Eriksen干扰任务中的脑电图（EEG）和行为数据，探讨MCI患者在干扰抑制方面的神经机制。 一组56名MCI患者和26名健康对照组（HCs）完成了具有一致性和不一致性刺激的任务，这些刺激的显著性水平各不相同。 在这些任务中，对α波段相干性的功能连接进行了分析，重点在于全局效率（GE），同时收集了反应时间（RT）和击中率（HR）。 我们的研究结果揭示了在GE、RT和HR上，一致性、显著性和认知状态之间存在显著的相互作用。 在HCs中，一致性条件下的GE更高（p = 0.0114，多元t分布校正，MVT），反应时间更快（p < 0.0001，MVT），击中率更高（p < 0.0001，MVT），与不一致性条件相比。 HCs在不一致性试验中显著性条件下的GE也有所增加（p = 0.0406，MVT）。 MCI患者在一致性条件下表现出优势，反应时间更短，击中率更高（两者p < 0.0001，MVT），但在GE适应性方面表现出下降，不同条件之间没有显著的GE差异。 这些结果突显了α波段相干性和GE作为认知障碍早期标志的潜力。 通过整合GE、RT和HR，本研究为神经效率、加工速度和任务准确性之间的相互作用提供了见解。 这种方法为认知负荷管理和干扰效应提供了有价值的见解，表明对改善MCI患者注意控制和加工速度的干预措施有益。 显示英文摘要

摘要： Mild Cognitive Impairment (MCI) is a critical transitional stage between normal cognitive aging and dementia, making its early detection essential. This study investigates the neural mechanisms of distractor suppression in MCI patients using EEG and behavioral data during an attention-cueing Eriksen flanker task. A cohort of 56 MCIs and 26 healthy controls (HCs) performed tasks with congruent and incongruent stimuli of varying saliency levels. During these tasks, EEG data were analyzed for alpha band coherence's functional connectivity, focusing on Global Efficiency (GE), while Reaction Time (RT) and Hit Rate (HR) were also collected. Our findings reveal significant interactions between congruency, saliency, and cognitive status on GE, RT, and HR. In HCs, congruent conditions resulted in higher GE (p = 0.0114, multivariate t-distribution correction, MVT), faster RTs (p < 0.0001, MVT), and higher HRs (p < 0.0001, MVT) compared to incongruent conditions. HCs also showed increased GE in salient conditions for incongruent trials (p = 0.0406, MVT). MCIs exhibited benefits from congruent conditions with shorter RTs and higher HRs (both p < 0.0001, MVT) compared to incongruent conditions but showed reduced adaptability in GE, with no significant GE differences between conditions. These results highlight the potential of alpha band coherence and GE as early markers for cognitive impairment. By integrating GE, RT, and HR, this study provides insights into the interplay between neural efficiency, processing speed, and task accuracy. This approach offers valuable insights into cognitive load management and interference effects, indicating benefits for interventions aimed at improving attentional control and processing speed in MCIs.