标题： 多巴胺-血清素意识理论 显示英文标题

标题： A Dopamine-Serotonin Theory of Consciousness

摘要： 这项工作提出了一个基于数学形式主义并得到临床数据分析支持的意识全面理论。 此处开发的框架表明，意识在高维神经化学空间中表现为连续的、非单调的函数，多巴胺作为主要强度调节器，血清素（5-HT2A）作为复杂性调节器。 这项工作为从深度睡眠和精神分裂症到神经死亡的最终崩溃的全部意识状态提供了机制解释。 该理论解释了矛盾现象，例如癫痫发作期间前额叶皮层的低活动性，精神分裂症易感个体的进化持续存在，以及为什么控制性给予经典5-HT2A激动剂在现代临床试验中严重医疗事件的发生率相对较低（<0.01%），而多巴胺能过度则迅速致命。 该框架使用来自242名帕金森病患者的70,290个睡眠夜晚数据进行测试，使用疾病严重程度（UPDRS）作为系统完整性的代理，使用药物（LEDD）作为多巴胺能输入的代理。 分析结果显示LEDD与UPDRS之间存在显著交互作用（beta=-1.7，p<.0001），证实了模型关于状态依赖性、非线性动态的预测。 显示英文摘要

摘要： This work presents a comprehensive theory of consciousness grounded in mathematical formalism and supported by clinical data analysis. The framework developed herein demonstrates that consciousness exists as a continuous, non-monotonic function across a high-dimensional neurochemical space, with dopamine serving as the primary intensity regulator and serotonin (5-HT2A) as the complexity modulator. This work offers mechanistic explanations for the full spectrum of conscious states, from deep sleep and psychosis to the ultimate collapse in neural death. The theory explains paradoxical phenomena such as prefrontal cortex hypoactivity during seizures, the evolutionary persistence of psychosis-prone individuals, and why controlled administration of classical 5-HT2A agonists shows a comparatively low incidence of serious medical events (< 0.01 % in modern clinical trials), while dopaminergic excess proves rapidly lethal. The framework is tested using 70,290 sleep nights from 242 Parkinson's disease patients, using disease severity (UPDRS) as a proxy for system integrity and medication (LEDD) as a proxy for dopaminergic input. The analysis reveals a significant LEDD x UPDRS interaction (beta=-1.7, p<.0001), confirming the model's prediction of state-dependent, non-linear dynamics.