标题： 界面泄漏：基于Persson接触力学理论的综合研究 显示英文标题

标题： Leakage at interfaces: a comprehensive study based on Persson contact mechanics theory

摘要： 我们基于Persson接触力学理论，对界面处的气体泄漏进行了全面研究。选择了一个由橡胶塞和玻璃筒组成的原型注射器系统，其中表面粗糙度通过触针轮廓仪和原子力显微镜的测量进行表征，接触压力分布则通过有限元法（FEM）计算获得。使用多尺度接触力学（MCM）软件进行泄漏预测。预测结果在受控干燥条件下与实验测量结果有良好的一致性。敏感性分析表明，弹性模量和接触压力的小幅变化可能会显著影响泄漏，尤其是在渗流阈值附近。这项工作为泄漏预测提供了一个通用且经过验证的框架，并为制药和工程应用中的密封系统设计提供了实用指导。 显示英文摘要

摘要： We present a comprehensive study of gas leakage at interfaces based on Persson contact mechanics theory. A prototype syringe system consisting of a rubber stopper and a glass barrel is selected, where surface roughness is characterized using measurements from stylus profilometry and atomic force microscopy, and contact pressure distributions are obtained from Finite Element Method (FEM) calculations. Leakage prediction is performed using Multiscale Contact Mechanics (MCM) software. The predicted results show good agreement with experimental measurements under controlled dry conditions. Sensitivity analyses indicate that small variations in elastic modulus and contact pressure can significantly influence leakage, particularly near the percolation threshold. This work provides a generalized and validated framework for leakage prediction and offers practical guidance for the design of sealing systems in pharmaceutical and engineering applications.