标题： 用于评估双生子研究中遗传影响的混合分布方法 显示英文标题

标题： A mixture distribution approach for assessing genetic impact from twin study

摘要： 这项工作受到一项双胞胎研究的启发，旨在评估免疫特征的遗传控制。 我们提出了一种混合二元分布来对双胞胎数据进行建模，其中配对中的潜在顺序不清楚。 尽管从混合分布中进行估计通常面临收敛速度低的问题，但结合了同卵双胞胎和异卵双胞胎的联合似然函数达到了根号n一致性，并允许对遗传影响进行有效的统计推断。 该方法适用于一般的无序配对。 显示英文摘要

摘要： This work was motivated by a twin study with the goal of assessing the genetic control of immune traits. We propose a mixture bivariate distribution to model twin data where the underlying order within a pair is unclear. Though estimation from mixture distribution is usually subject to low convergence rate, the combined likelihood, which is constructed over monozygotic and dizygotic twins combined, reaches root-n consistency and allows effective statistical inference on the genetic impact. The method is applicable to general unordered pairs.