标题： 二维细胞聚集体中的密度依赖输运系数 显示英文标题

标题： Density-dependent transport coefficients in two-dimensional cellular aggregates

摘要： 生物系统的宏观集体行为可以通过宏观输运来表征，这种输运源于个体组分之间的非平衡微观相互作用。 一个显著的例子是运动的真核细胞或细菌通过主动收缩力形成的动态聚集体。 在这项工作中，我们基于\textit{淋病奈瑟菌}细菌聚集模型系统的微观动力学，发展了二维涨落流体力学理论。 推导出决定细胞水动力电流的体扩散系数和导电性的两个宏观输运系数是本工作的核心结果。 通过展示输运系数如何依赖于细胞密度和系统的微观参数，我们预测了在菌落形成过程中输运减慢的现象。 这项研究为量化由于间歇性收缩偶极子力导致的细胞聚集实验系统中的水动力输运提供了有价值的分析工具。 显示英文摘要

摘要： The large-scale collective behavior of biological systems can be characterized by macroscopic transport, which arises from the non-equilibrium microscopic interactions among individual constituents. A prominent example is the formation of dynamic aggregates by motile eukaryotic cells or bacteria mediated by active contractile forces. In this work, we develop the two-dimensional fluctuating hydrodynamics theory based on the microscopic dynamics of a model system of aggregation by \textit{Neisseria gonorrhoeae} bacteria. The derivation of two macroscopic transport coefficients of bulk diffusivity and conductivity which determine hydrodynamic current of cells is the central result of this work. By showing how transport coefficients depend on cell density and microscopic parameters of the system we predict transport slowdown during the colony formation process. This study provides valuable analytical tools for quantifying hydrodynamic transport in experimental systems involving cellular aggregation occurring due to intermittent contractile dipole forces.